80岁以上老年人多重用药的临床观察

摘要

Objective To study the current situation of multiple drug use in elderly people over 80 years old and the relationship between the type and quantity of medication and adverse drug reactions.Methods The hospitalized patients aged >80 years were collected.The drug kinds and numbers of patients with discharge were recorded.Outpa-tients were followed up for 3 months and their medication and related adverse reactions were recorded.Results Total of 119 elderly people were included in this study,including 78 males and 41 females; their ages ranged from 80 to 99 years.In the elderly,the average per capita drug intake was(6.7 ±4.2),and the average per capita drug consumption was(20.2 ±8.6).The prevalence of multiple drug use was 82.4%(98 persons).The increase of the kinds and num-bers of oral drugs could cause ADR The incidence of significant increase.Conclusions The prevalence of polypharma-cy is high and caused the increasing of ADR.Instructions should be given to the aged to improve the patient′s quality of life and the compliance of medicine.%目的 研究≥80岁老年人多重用药现状及服药种类和数量与药物不良反应(ADR)发生的关系.方法 收集119例年龄≥80岁的住院患者病例资料,记录出院带药种类和数量;并对其进行3个月的门诊随访,记录其服药情况和相关不良反应种类和数量.结果 119例老年人中,临床诊断最多者12项,平均6项.多重用药(日口服用药种类>5种)98例(占82.4%),且多重用药者发生率的增加与年龄增长有显著相关性;出院带药种类最多者12种,人均(6.7 ±4.2)种;出院带药每日口服药物数量最多者42粒,人均服药数量(20.2 ±8.6)粒;口服药的种类与数目的增加均会使得ADR发生率显著增长.结论 ≥80岁老年人多重用药现状不容乐观.老年人随年龄增长带来的慢性疾病增加、用药种类数目上升,导致ADR的增加.应加强医护人员对老年人的用药指导,以降低老年人多重用药的程度,减少药物不良反应.