氟哌噻吨美利曲辛联合胃电起搏对功能性消化不良患者胃电活动的影响

摘要

目的 探讨氟哌噻吨美利曲辛联合胃电起搏对功能性消化不良(FD)患者的临床疗效和胃电活动的影响.方法 选择门诊或病房就诊的60例FD患者,其中30例仅经胃电起搏治疗(单一治疗组),另30例经氟哌噻吨美利曲辛联合胃电起搏治疗(联合治疗组),疗程均为12周,治疗前后分别采用胃电图检测,对胃电参数进行分析,并对两组患者进行症状评分、焦虑评分、抑郁评分.结果 治疗12周后:(1)联合治疗组的胃电节律紊乱系数较单一治疗组的小[(12.08 ±2.23)分比(36.41 ±13.34)分,P<0.05)],慢波频率、餐后与餐前功率比值、慢波幅值、反应面积较单一治疗组的大[(3.12 ±0.39)CPM 比(2.33 ±0.23)CPM,(1.24 ±0.78)比(0.63 ±0.23),(187.62 ±61.79)μV比(138.25 ±33.94)μV,(60.34 ±20.56)μV· S比(48.99 ±22.27)μV· S,均P<0.05].(2)联合治疗组的临床症状评分较单一治疗组的评分显著降低[(3.07 ±1.87)分比(8.98 ± 3.92)分,P<0.05],联合治疗组的总有效率显著高于单一治疗组的总有效率(56.67%比33.30%,P<0.05).(3)联合治疗组的HAMA评分显著低于单一治疗的组评分[(12.23 ±9.56)分比(20.65 ±7.82)分,P<0.05)];联合治疗组的HAMD评分显著低于单一治疗组的评分[(13.20 ±7.76)分比(18.87 ±9.52)分,P<0.05)].结论 氟哌噻吨美利曲辛联合胃电起搏可以改善胃电波形,迅速缓解功能性消化不良的症状.%Objective To investigate the effect of dropetithiotunmeritriaxine in combination with gastric electri-cal pacing in patients with functional dyspepsia.Methods Sixty patients with FD were enrolled in our outpatient or ward,and were randomly divided into single treatment group(n=30)and combined treatment group(n=30),single treatment group were treated with gastric pacing only,and the combined treatment group were treated with combination of Dropetithiotunmeritriaxine and gastric electrical pacing.The course of treatment was 12 weeks.Before and after treat-ment,the gastric electrogastrogram(GGD)was used to analyze the parameters of gastric electrical activity.Symptom scores,anxiety scores and depression scores were compared between the two groups.Results The coefficient of gastric rhythm disorder in the combined treatment group was smaller than that in the single treatment group[(12.08 ±2.23) points compare to(36.41 ±13.34)points,(P<0.05)].Slow wave frequency,postprandial pre-meal power percentage, slow wave amplitude,and response area were larger than those in single treatment group[(3.12 ±0.39)CPM compare to (2.33 ±0.23)CPM,(1.24 ±0.78)compare to(0.63 ±0.23),(187.62 ±61.79)μV compare to(138.25 ±33.94) μV,(60.34 ±20.56)μV· S compare to(48.99 ±22.27)μV· S,P<0.05].Clinical Symptom Score:The score of the combination group was significantly lower than that of the single treatment group[(3.07 ±1.87)points compare to (8.98 ±3.92)points,P<0.05].Efficacy score:the total effective rate of the combined treatment group was significant-ly higher than the single treatment group(56.67% compare to 33.30%,P<0.05).HAMA score:The score of the combination group was significantly lower than that of the single treatment group[(12.23 ±9.56)points compare to (20.65 ±7.82)points,P<0.05)].HAMD score:The score of the combination group was significantly lower than that of the single treatment group[(13.20 ±7.76)points compare to(18.87 ±9.52)points,P<0.05].Conclusion Dropetithiotunmeritriaxine combined gastric electrical pacing can speed up gastric motility,improve gastric waveform,and quickly alleviate the symptoms of functional dyspepsia.