GSTM1和GSTT1基因多态性与抗结核药物性肝损害的关系

摘要

Objective To investigate the relationship between the genetic polymorphisms of glutathione S-transferase Ml, T1(GSTM1, GSTT1) and the susceptibility of antituberculosis drug-induced hepatotoxicity (ATDLI) in the tuberculosis patients of Chinese Han population. Methods Genetic polymorphisms of GSTM1, GSTT1 were analyzed in tuberculosis patients treated with or without hepatotoxicity after antituberculosis drug using multiple PCR method. Resultes The frequencies of GSTM1 null genotype were 58.3% in the ATDLI patients and 50.7% in controls (OR=1.363, 95%CI=0.963~1.929), which the difference was not significant (P>0.05). The frequencies of GSTT1 null genotype were 45.2% in the ATDLI patients and 49.3% in controls, which the difference was also not significant (P>0.05). The variation frequency of the combination of GSTM1 and GSTT1 between case group and control group had not statistically difference (P>0.05). They had not synergistic effect in the development of ATDLI. Conclusion GSTM1 and GSTT1 genotypes might have no association with risk of the ATDLI in Chinese Han population.%目的 探讨汉族人群谷胱甘肽S转移酶M1(GSTMl)和T1(GSTT1)基因多态性与抗结核药物性肝损害(ATDLI)易感性的关系.方法 回顾性分析抗结核治疗后发生肝损害的结核病患者228例(病例组)及未发生肝损害的结核病患者300例(对照组),应用多重PCR技术检测其GSTM1和GSTT1基因多态性.结果 病例组与对照组GSTM1基因缺失型频率分别为58.3％和50.7％,差异无统计学意义(OR=1.363,95％CI=0.963～1.929); GSTT1基因缺失型频率分别为45.2％和49.3％,差异也无统计学意义.联合分析也未发现两种基因在抗结核药物性肝损害发生中具有协同作用.结论 汉族人群GSTM1和GSTT1基因多态性与抗结核药物性肝损害的发生无关.