Pharmaceutical cocrystal could be obtained by combining active pharmaceutical ingredient (API) and cocrystal former (CCF) in one crystal lattice through noncovalent interaction.It is a new pharmaceutical physical form which can improve the physicochemical properties, such as solubility, stability and bioavailability of API.It has becoming a novel hot spot in pharmaceutical research and development field.This paper mainly introduces the pharmaceutical cocrystal on its application, design, preparation and analysis method.%药物共晶是活性药物成分通过非共价键和共晶形成物结合在一个晶格中形成的.它是一种新的药物固体型态,可以改善药物的理化性质,比如改善溶解度、增加稳定性、提高生物利用度等,是目前药物研发的一个新的热点.本文主要介绍了药物共晶在药物研发中的应用及其设计、制备以及分析方法.
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