国产与进口头孢呋辛钠治疗细菌性感染的药物经济学评价

摘要

Objective To assess the efficiency and safety of the domestic and imported cefuroxime sodium for bacterial infection, and then compare pharmacoeconomic evaluation of the two. Methods Collecting all clinical trials by searching associated batabase.the total effective rate, bacterial eradication rates, adverse effect rates as an indicator then meta-analysis of domestic and imported cefuroxime sodium for bacterial infection. Results A total of 11 RCTs and 873 patients were enrolled. The effective rate of domestic cefuroxime sodium and imported one is [OR 1.03, 95%CI (0.66, 1.61), P 0.90] 、 the bacterial eradication rates is [OR 0.78, 95%CI (0.44, 1.40), P 0.40] and the adverse effect rates is[OR 0.95, 95%CI (0.58, 1.54), P 0.83]. The minimum cost method shows that the imported cefuroxime sodium costs higher. Conclusion The currently available evidence shows that there are no significant difference of the total effective rate, bacterial eradication rates and adverse effect rates between the domestic cefuroxime sodium and the imported one and the domestic cefuroxime sodium costs lower.%目的 比较国产与进口头孢呋辛钠治疗细菌性感染的临床有效性及安全性,进一步对两种药物进行药物经济学评价.方法 检索所需要的数据库,对符合纳入标准的国产与进口头孢呋辛钠治疗细菌感染的文献进行Meta分析,以临床总有效率、细菌清除率、不良反应发生率作为指标,用最小成本法进行药物经济学评价.结果 共检索到11个试验,包括873名患者.国产与进口头孢呋辛钠的临床有效率、细菌清除率及不良反应发生率的比较分别为[OR 1.03,95％CI (0.66,1.61),P 0.90]、[OR 0.78,95％CI(0.44,1.40),p0.40]、[OR 0.95,95％ CI(0.58,1.54),P0.83].最小成本法表明,进口头孢呋辛钠的成本较国产高.结论 现有证据表明,国产与进口头孢呋辛钠治疗细菌性感染的临床疗效、细菌清除率及不良反应发生率均无显著性差异.国产头孢呋辛钠的经济学价值高于进口.