MicroRNA和肿瘤转移关系的研究进展

摘要

Within the past few years, studies on MicroRNA (miRNA) and tumor metastasis have become the focus of attention. Multiple lines of evidence demonstrated the involvement of specific miRNAs in tumor metastasis, which can negatively regulate the expression of target mRNA and post-transcriptionally control gene expression. Metastasis is the key indicator of tumor malignancy and is the main reason of death of the tumor patients, so how to prevent and control it is important to increase the survival of the tumor patients. This review summarized the recent progress on the research field of miRNA and its association with tumor metastasis.%近年来,关于MicroRNA(miRNA)与肿瘤转移关系的研究成为探讨肿瘤转移调控机制的热点.诸多研究表明,miRNA在肿瘤转移过程中起着关键作用,它主要以干预mRNA翻译的方式负向调控基因的表达,参与肿瘤转移的发生发展.肿瘤转移是恶性肿瘤的基本生物学特征,是临床恶性肿瘤患者的重要死因,研究miRNA对恶性肿瘤转移发生发展的作用有助于我们寻找治疗恶性肿瘤转移的新方法.本文就miRNA和肿瘤转移关系的研究进展做一综述.