Pancreatic cancer is a kind of digestive system cancer, known as highly malignant, rapid progression, low resection rate and poor prognosis. Patients often lose the chance of radical resection surgery because of late diagnosis. Radiotherapy, chemotherapy as well as other treatments are also not satisfactory. In recent years, with the development of intervention technology, minimally invasive intervention therapy has become a key research direction which can improve the quality of life and prolong the survival rate. Of those, the intra-arterial infusion chemotherapy, with its relative efficiency, safety, simplification, and lower complications and toxicity, has been one of the important treatments technique for unresectable patients. What's more, the new adjuvant chemotherapy mainly by intra-arterial chemotherapy has a remarkable significance in improving the resection rate and overall survival. Under the current hot point research on the tumor gene therapy for cancer, target therapy combined with intra-arterial therapy may be a promising direction for the treatment of pancreatic cancer.%胰腺癌是一类恶性程度高、病情进展迅速、手术切除率低且预后极差的消化系统恶性肿瘤.患者常由于早期诊断困难而失去手术根治性切除的机会,且放、化疗等治疗效果不尽如人意.近年来,随介入技术的不断发展,微创性介入治疗已成为提高生存质量、延长生存期的重点研究方向之一.其中,经动脉灌注的介入联合化疗以其相对高效、安全、简便、并发症和不良反应较低等优点,成为无法手术切除的患者延长存活期,提高生活质量的重要治疗手段之一；而以动脉介入为主的新辅助治疗对提高患者的手术切除率以及生存率具有显著意义.在基因治疗成为肿瘤治疗研究热点的现况下,靶向治疗与介入治疗的结合将成为临床胰腺癌治疗的一个具有广阔发展前景的方向.
展开▼
