长链非编码RNA在肿瘤发生、发展中的作用研究现状

摘要

At present, long non-coding RNAs (lncRNAs) are hot spots which are different from other smaller non-coding RNAs. Through researches, IncRNAs have been found to affect species evolution, embryonic development,metabolism and tumorigenesis. Research of IncRNAs will make revolutionary changes in the understanding of the networks of cell structure, regulatory networks, as well as provide scientific evidence for future diagnosis and treatment of clinical diseases, especially in human tumors. In this review, we summarized research in the current status of IncRNAs in human tumors.%长链非编码RNA(long non-coding RNA,IncRNA),有别于其他小分子非编码RNA,是目前非编码RNA研究的热点.随着研究的不断推进,人们发现lncRNA与物种进化、胚胎发育、物质代谢以及肿瘤发生等都有着密切的联系,其功能的深入研究将使目前对细胞的结构网络和调控网络的认识带来革命性的变化,也为未来临床疾病尤其是肿瘤的诊断和治疗提供非常有价值的科学依据.本文对IncRNA在人类肿瘤发生、发展中的研究现状作一综述.