小细胞肺癌分子遗传学研究进展

摘要

小细胞肺癌(small cell lung cancer，SCLC)恶性程度高、预后差，现有的靶向药物治疗基本无效，迫切需要深入了解其分子特征从而筛选有效的治疗靶点。二代测序等全基因组研究技术为肿瘤的研究、诊治批量增加遗传标志物，SCLC的遗传位点亦不断被发现和解读。本文对近年SCLC分子遗传特征的研究进展进行综述。%Small cell lung cancer (SCLC) is an aggressive malignancy with fairly poor prognosis. Innovative treatment based on improved understanding of the genetic alterations of SCLC is awaited. Recently, a number of potential targets or important oncogenic pathways have been identified by the next generation sequencing or other systematic genomic analysis in SCLC. In this review, we summarised the new ifndings of genetic characteristics in SCLC.