Objective To study whether L-carnitine has beneficial impact on gentamicin (GM)-induced acute renal failure (ARF). Methods Adult male SD rats were assigned to four groups (A, B, C, D): the rats of group A were injected normal saline for 8 consecutive days; the rats of group B were injected GM [80 mg/(kg·d)] for 8 days; the rats of group C were injected L-carnitine [200 mg/(kg·d)] for 8 days; the rats of group D were injected GM [80 mg/(kg·d)] 1 hour after L-carnitine [200 mg/(kg·d)] injection for 8 days. Then, the blood, urine were collected in the ninth day, the biochemical indicators were detected, and to observe the morphological changes of kidney tissue. Results Compared with group A and C, concentration of serum blood urea nitrogen (BUN), creatinine (Cr) and urinary protein significantly increased and the total urine decreased in group B (P < 0.01, P < 0.05). Compared with group B, concentration of BUN, Cr and urinary protein significantly decreased and urince increased in group D (P < 0.05). Conclusion L-carnitine has protective impact on gentamicin-induced acute renal failure.%目的 检测L-肉毒碱是否对庆大霉素诱导的急性肾衰竭具有保护作用.方法 将成年雄性SD大鼠随机分为A、B、C、D 4组,各组连续8 d分别于腹腔内注射不同药物:A组注射生理盐水,B组注射庆大霉素[80 mg/(kg·d)],C组注射L-肉毒碱[200 mg/(kg·d)],D组依次注射L-肉毒碱[200 mg/(kg·d)]和庆大霉素[80 mg/(kg·d)],两次给药时间间隔1 h.各组大鼠分别于给药后第9天采集血液、尿液,检测生化指标,观察肾脏组织形态学改变.结果 与A组和C组相比,B组大鼠血清尿素氮(BUN)、肌酐(Cr)、尿蛋白含量增加,尿液总量减少,差异有统计学意义(P < 0.01、P < 0.05).与B组相比,D组血清BUN、Cr含量明显减少,尿蛋白减少,尿量增加,差异有统计学意义(P < 0.05).结论 L-肉毒碱对庆大霉素诱导的急性肾衰竭具有保护作用.
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