Objective This paper aims to explore the relationship between axillary lymph node metastasis and ultrasonography (US) and contrast-enhanced ultrasonography (CEUS), and investigates the application value of them. Methods The US and CEUS of 141 patients with breast cancer and lymphatic metastasis were retrospectively analyzed. Single factor analysis and multi-factor logistic analysis were respectively used to investigate the correlation with above factors and axillary lymph node metastasis. Results Single factor analysis showed the clinical data including perfusion imaging sequence, tumor grade, lymph node acoustic halo, enhanced peripheral of lymph node, enhanced pattern, diameter enlarged, cortical thickness, aspect ratio, and relative difference of the area under curve (AUC) in primary foci (P<0.05). Multi-factor analysis showed that enhanced pattern, after contrast, diameter enlarged of lymph node were risk factors for breast cancer with axillary lymph node metastasis (P<0.05). Conclusion Therefore, it is inferred that CEUS characteristic of axillary lymph node metastasis has an important guiding role in the identification of axillary lymph node metastasis of breast cancer clinically.%目的 为探讨乳腺癌腋窝淋巴结转移的超声造影相关因素,并分析其应用价值.方法 对141例经病理证实的乳腺癌患者的临床资料进行回顾性分析,观察影响腋窝淋巴结转移的常规超声及超声造影相关因素,经单因素和多因素Logistic回归分析,检验上述因素与腋窝淋巴结转移的相关性.结果 研究发现影响乳腺癌腋窝淋巴结转移的相关因素有淋巴结周边声晕、乳腺肿瘤血流分级、淋巴结灌注顺序、淋巴结增强方式、淋巴结边缘增强、淋巴结径线扩大、淋巴结纵横比、淋巴结皮质最大厚度、及乳腺癌原发灶相对曲线下面积差(P<0.05),而多因素Logistic回归分析则显示其中淋巴结增强方式、造影后淋巴结径线扩大是乳腺癌腋窝淋巴结转移的危险因素(P<0.05).结论 超声造影对乳腺癌腋窝淋巴结转移的鉴别有重要意义.
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