女性外阴尖锐湿疣患者伴发宫颈高危型HPV感染的研究

摘要

Objective: To determine the infection of cervical high risk human papillomavirus (HR- HPV) infection in female patients with vulvar condyloma aeuminatum (VGA). Methods: Hyhrid capture 2 ( HC2) was employed to detect HR - HPV DNA in cervical samples from 112 women with VGA. Results: Out of 112 patients, 74 patients were positive for HR- HPV UNA, giving a positivity rate of 66.07%(74/112). Among the women with HR -HPV UNA, 42 women had normal LCT report,32 with mild cervical lesions (20 of atypical squamous cells of undetermined significance and 12 of low - grade squamous intraepithelial lesion) and there was no significant difference in average level of viral load between the two conditions ( P > 0.05). Conclusion: Cervical HR - HPV infection is very common in patients with VGA. Routine screening for cervical HR - HPV infection is necessary.%目的: 确定女性外阴尖锐湿疣患者宫颈高危型HPV的感染.方法: 采用美国FDA批准的第二代杂交捕获试验对112例女性外阴尖锐湿疣患者的宫颈脱落细胞进行高危型HPV DNA检测.结果:112例患者中,宫颈高危型 HPV DNA阳性率为66.07％(74/112),其中子宫颈薄层液基细胞学检测(LCT)正常者42例,轻度宫颈上皮细胞病变者32例(非典型鳞状细胞20例,低度上皮内病变者12例),伴有宫颈上皮细胞病变与否在高危型HPV DNA平均载量方面无显著性差异(P＞0.05).结论: 女性尖锐湿疣患者常合并宫颈高危型HPV感染,有必要进行宫颈高危型HPV常规检测.