HtrA2/Omi、XIAP和Caspase-3在银屑病皮损中的表达

摘要

Objective; To detect the expiessbn of H trA2/0m I, X linked iihiibr of apoptosis (XRP) and Caspase 3 ii psorktic lesins. M eihods: SABC inmunohikhchem istiy was used to detectihe expression of H trA2/ Om I, X]AP and Caspase 3 ii he Jesrinsof 30 patieniswilh psoriasis vufearis (PV ) and 10 heaUiy volunteers. The correktbn of H trA2/0m I, X]AP and Caspase 3 was analyzed . R esulls: Canpaied "b noun alskii, the expiessin of XIAP and Caspase 3 weie increased ii PV lesbns (P<0 .01) , but no difference was found beteeen H trA2/0m I and nom alskin ( P>0 .05) . ]n psoria.tc lesin , "the level of Caspase 3 waspositi'ely conekted w ih XIAP ( P< 0 .05) , while Iheie was no signiExant conektbn beteeen "the levelof Caspase 3 and H trA2/0m I ( P>0 .05) , and beteeen H trA2/0m I and XZIAP ( P>0 .05) . Conclisi3n: XIAP and Caspase 3 m ay play an in portent lole ii "the palhogenesis of psoriasis vulgaris.%目的:检测HtrA2/Omi,X 染色体连锁凋亡抑制剂(X - linked inhibitor of apoptosis,XIAP )和半胱天冬酶- 3(Caspase-3)在寻常型银屑病(PV )中的表达.方法:应用免疫组化SA BC 法检测30 例PV 皮损与10 例正常人皮肤中HtrA2/Omi、XIAP 和Caspase-3 的表达,并分析HtrA2/Omi、XIAP 和C aspase- 3 表达之间的相关性.结果:PV 皮损中XIAP 和Caspase-3 阳性细胞数明显高于正常皮肤(P＜0.01),HtrA2/Omi阳性细胞数与正常皮肤无明显差异(P＞0.05).Caspase-3 阳性细胞数和XIAP 呈正相关趋势(P＜0.05),与HtrA2/Omi表达无明显相关性(P＞0.05).HtrA2/Omi和XIAP 的表达无明显相关性(P＞0.05).结论:XIAP 和Caspase-3 可能在PV 的发病中起重要作用.