Objective: To analyze the pathological features of malignant melanoma of Xinjiang uygur. Methods: the pathological features were analyzed after HE staining and immunohistochemistry in 26 patients with malignant melanoma. Results: The histopathological structures and morphological characteristics of malignant melanoma were complex. The main features of melanoma under light microscopy showed a variety of histological features, including epithelioid cell type, spindle cell type, nevus - like cell type, hylocyte cell type and mixed cell type. The immunohistochemistry showed that the positivity rates of HMB - 45, S - 100, Ki - 67, Vimentin, Melan - A were 90% , 100% , 100% ,90% and 96% respectively. Conclusion: The melanoma has a variety of clinical manifestations and the diagnosis mainly depends on histopathological and immunohistochemistry findings.%目的:分析新疆维吾尔族恶性黑素瘤的病理学特征.方法:收集26例新疆维吾尔族恶性黑素瘤,采用HE染色和免疫组化标记,进行病理分析.结果:恶性黑素瘤的组织结构及病理形态复杂多样性,以多种细胞类型和组织形态混合存在为主要特征,细胞类型可分为:上皮样细胞型、梭形细胞型、小痣样细胞型、气球样细胞型、混合型.免疫组化标记瘤细胞表达HMB-45、S-100、Ki-67、Vimentin、Melan-A分别为90％、100％、100％、90％、96％.结论:恶性黑素瘤临床表现复杂,其诊断及鉴别诊断主要依靠病理学、免疫组化检查.
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