痤疮的抗生素治疗及耐药现状

摘要

痤疮丙酸杆菌在痤疮发生、发展过程中起着重要作用,外用或口服抗生素对痤疮炎性皮损有肯定疗效.然而随着抗生素的广泛使用,耐药问题日益严峻,研究表明超过50％的痤疮丙酸杆菌出现了耐药,尤其是对大环内酯类抗生素.本文对抗生素治疗痤疮的作用机理与使用现状、耐药机制与耐药现状进行综述.%Propionibacterium acnes play an important role in the development of acne. Topical or oral anti-biotics have definite effects on the inflammatory lesions of acne. However, the concern of antibiotic resistance is increasingly more serious with the widely use of antibiotics. It is reported that over 50％ of Propionibacteri-um acnes strains are resistant to antibiotics,especially to macrolides. The action mechanisms and status of an-tibiotic for the treatment of acne, the resistance mechanisms and status of antibiotic resistance are reviewed in this article.