生物医用高强度水凝胶的研究进展

摘要

水凝胶是一种高含水量的三维网状聚合物,广泛应用于各个领域,但力学性能较差的特点限制了其在生物医用领域的应用。因此,如何提高水凝胶的力学强度成为国内外专家学者研究的重点。本文主要介绍了几种新型高强度水凝胶的合成及研究进展,包括滑动水凝胶、双网络水凝胶、复合水凝胶以及其它水凝胶,详细分析了影响这些水凝胶力学性能的因素。指出研制具有生物相容性、可生物降解、可注射、可负载活性因子并且具备良好的力学性能水凝胶是今后的研究方向。%Hydrogels are there-dimensional polymer network in which the voids are filled with water. Hydrogels have been widely used in various fields including biomedical engineering. However, they have very limited applicability due to their poor mechanical strength. Therefore, many efforts have been focused on the enhancement of mechanical properties of hydrogels. This review mainly introduces some novel high strength hydrogels, such as slide-ring hydrogels, double network hydrogels, composite hydrogels and others and analyzes the factors affecting mechanical properties of hydrogels. Biocompatible, degradable, injectable, loading growth factor and high strength hydrogels as major research directions.