新型ALG-g-Lys微胶珠的制备工艺优化

摘要

为了提高海藻酸钙胶珠的稳定性，采用海藻酸盐的改性材料 ALG-g-Lys 制备微胶珠，通过单因素考察结合正交设计优化了 ALG-g-Lys微胶珠的制备工艺。优化后的制备工艺为：ALG-g-Lys 浓度为15g/L，电压为8.0kV，推进速度为30mm/h，针头型号为24G，CaCl2浓度为15g/L。优化后制得的微胶珠粒径均匀，球形度好，拖尾率、半球率和小球率小，平均粒径为253±40μm。该工作提供了一种新型的载体材料替代海藻酸盐作为凝胶材料，未来可适用于医药、食品行业等领域。%A new material,ALG-g-Lys,was used to prepare micro-beads instead of alginate to improve the stability of alginate micro-beads. The preparation process was optimized using the single factor method combined with orthogonal design. The optimized parameters were:ALG-g-Lys concentration 1.5g/L,voltage 8.0kV,advance speed 30mm/h,needle 24G,and CaCl2 concentration 15g/L. The prepared micro-beads showed even distribution and good sphericity with low trailing ratio,half sphere ratio and globule ratio. The mean particle size was 253±40μm. This work supplies a novel carrier material instead of alginate to prepare gel, showing bright future in medicine and food industries.