CD28 costimulation promotes an antitumor CD8^(+) T cell response in myeloid antigen-presenting cell niches

摘要

Ectopic lymphoid structures found within the tumor stroma,such as tertiary lymphoid structures(TLSs),are predictive markers of immune checkpoint blockade(ICB)in solid tumors.In a recent study in Cancer Cell,Duraiswamy et al.highlighted other immune structures,such as myeloid antigen-presenting cell(APC)niches,in the context of high-grade serous ovarian cancers(HGSOCs)[1].In these structures,programmed cell death receptor 1(PD-1)^(+)tumor-infiltrating T lymphocytes(TILs)undergo a full activation program(a license to kill)via the CD28 costimulatory molecule during PD-1 blockade in HGSOC.