首页> 中文期刊> 《细胞与分子免疫学:英文版》 >Emerging roles of bile acids in chronic hepatitis,liver cirrhosis,and hepatocellular carcinoma

Emerging roles of bile acids in chronic hepatitis,liver cirrhosis,and hepatocellular carcinoma

     

摘要

Bile acids(BAs)are cholesterol-derived molecules that are produced in the liver,secreted into the duodenum,absorbed by the small intestine and recycled back to the liver[1].BAs regulate cholesterol metabolism,promote bile secretion,and emulsify and facilitate the digestion and absorption of dietary fats;in addition,there is growing evidence that BAs also act as endocrine cell signaling mediators that activate nuclear or membrane-localized receptors to trigger specific signaling pathways and regulate various biological processes,including immunity[2,3].Findings from studies in patients and cell or mouse models support the notion that BAs are critical regulators of the development of liver diseases,including chronic hepatitis B(CHB)[4],liver cirrhosis(LC)[5],and hepatocellular carcinoma(HCC)[6].Here,we discuss the emerging roles of BAs in the progression of CHB,LC,and HCC.

著录项

  • 来源
    《细胞与分子免疫学:英文版》 |2023年第9期|1087-1089|共3页
  • 作者

    Zhen Xun; Xiaobao Yao; Qishui Ou;

  • 作者单位

    Department of Laboratory Medicine;

    Fujian Key Laboratory of Laboratory Medicine;

    Gene Diagnosis Research Center;

    Fujian Clinical Research Center for Clinical Immunology Laboratory Test;

    The First Affiliated Hospital;

    Fujian Medical University;

    Fuzhou;

    China;

    Department of Laboratory Medicine;

    National Regional Medical Center;

    Binhai Campus of the First Affiliated Hospital;

    Fujian Medical University;

    Fuzhou;

    China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 肿瘤学;
  • 关键词

    bile; cirrhosis; metabolism;

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