Scientists at Cincinnati Children’s Hospital Medical Center report that an innate molecular signaling hub known as the ripoptosome plays a key role in the development of allergic pathologies and suggest that manipulation of this response platform could open new paths for the treatment of allergic diseases[1].Allergies are an unremitting global health care problem.Although the symptoms of affected individuals are well documented for a wide range of allergic disorders,the precise molecular mechanisms that trigger allergic inflammation to innocuous substances remain elusive.Thus,a key question in allergy research is why certain environmental proteins can trigger the induction of allergic Th2 responses.Seminal work by Ruslan Medzhitov’s group identified protease activity inherent in many allergens as being critical to eliciting the hypersensitivity response.
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