In their recent article in Nature Immunology,Fujiwara et al.identified reduced mitochondrial respiration and increased succinate levels in intestinal epithelial cells(IECs)from several distinct models of T cell-mediated colitis.Their observations point to a specific link between alterations in the mitochondrial complex II component SDHA and the severity of T cell-mediated intestinal diseases and suggest that SDHA dysfunction could be a diagnostic and/or prognostic biomarker in T cell-mediated immunopathology.
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机译:modulatory effects of antimicrobials on panton-Valentine Leukocidin gene expression in community-associated methicillin-resistant staphylococcus aureus in vitro and disease severity in vivo in a murine model.