Opposing roles of conventional and novel PKC isoforms in Hippo-YAP pathway regulation

摘要

Dear Editor, The Hippo-YAP pathway is an evolutionally conserved signaling module that controls tissue growth during development and its dysregulation causes cancer [1].Core components of the Hippo pathway include a kinase cascade comprising MST1/2 and LATS1/2 kinases,in which MST1/2 phosphorylates and activates LATS1/2 [2].