Effect of Xinjikang on left ventricular hypertrophy remodeling in hypertensive rats

摘要

Objective:To investigate the effects ofXinjikang on the left ventricular hypertrophy remodeling and myocardial activity in hypertension.Methods:SixtyWistar rats were randomly divided into four groups.The pressure-loaded left ventricular hypertrophy model was established with abdominal aorta ligation method.Rats inA andB groups were intragastrically administered with physiological saline, whileC andD groups were administered withXinjikang and metoprolol, respectively.The changes in blood pressure,E/A ratio, myocardial pathological morphology, myocardial lipoperoxides and superoxide dismustase activity in four groups were observed and compared before and after treatment. Results:There were statistically significant differences inE/A ratio betweenC group after treatment and model group(P<0.05), whileno difference was observed betweenA andD groups(P>0.05); after treatment the myocardial lipoperoxides and superoxide dismustase contents inC andD groups were improved significantly compared with model group(P<0.05).Conclusions:Xinjikang can improve myocardial injury, restore myocardial parenchyma and myocardial interstitial remodeling functions in hypertensive rats with the left ventricular hypertrophy.