Evaluation of directly observed treatment short courses at a secondary health institution in Ibadan, Oyo State, Southwestern Nigeria

摘要

Objective:To evaluate the success rate of tuberculosis intervention programme at a specialist hospital inIbadan,Nigeria through a retrospective study as well as carry out physicochemical evaluation of anti-tuberculous agents as a way of eliminating drug-related failure.Methods:The retrospective study involved the use of quarterly tuberculosis central register at theGovernment ChestHospital,Ibadan between1st quarter(2003) to4th quarter(2009).Relevant data were extracted from these register with the aid of data collection forms.The basic physicochemical analyses of the drugs given to the patients were also carried out using theInternational Pharmacopoeia methods.Results:All the drugs examined for their physicochemical properties passed theInternationalPharmacopeia recommended tests.A total number of1260 patients enrolled at the hospital were assessed through case notes.This comprises of59.4% males of which 69.23% new cases were also males.There was a significant(P<0.05) patient enrollment across the quarters for the seven years.An overall80.24% cure rate over the7-period was obtained which is less than theWHO target of85%.Cure rates were better in females than males.Failure treatment outcomes such as positive(1.51%), deaths(8.73%), defaulted(3.33%) and transferred out(5.95%) were recorded though not statistically significant(P>0.05).Failure rates in all categories were higher in males than females(P>0.05).Conclusions:More enlightenment and counseling is still required to meet up with the target forTB control.