细胞外钾离子浓度延迟恢复对螺旋波的影响研究∗

摘要

在Luo-Rudy相I心脏模型中考虑了细胞外钾离子浓度的频率依赖性，并研究了细胞外钾离子浓度的延迟恢复对螺旋波动力学的影响。数值模拟结果表明，在螺旋波态下，细胞外钾离子浓度的延迟恢复会导致细胞外钾离子浓度周期振荡，其振荡周期和振幅随延迟恢复时间的增加而增加，进而导致出现呼吸螺旋波、多螺旋波共存、螺旋波做Lévy飞行式漫游、螺旋波通过不同方式消失等现象，这些结果与实验结果一致。%Frequency-dependent changes in the extracellular potassium ion concentration have been added to the Luo-Rudy phase I heart model. Effects of the delayed restoration of extracellular potassium ion concentration on spiral waves are studied. Numerical simulation results show that due to the state of spiral wave, the delayed restoration of extracellular potassium ion concentration can lead to periodic oscillations of concentration, and the period and amplitude of the oscillation increase with the delayed recovery time, resulting in the emergence of various phenomena, such as the breathing spiral wave, the coexistence of multiple spiral waves, the meandering of spiral waves in the manner of Lévy flight, and the disappearance of spiral wave through different ways. These results are compatible with the experimental results.