声明
ABSTRACT
摘要
Table of Contents
List of Tables
List of schemes
Chapter 1 Exordium
1.Introduction
1.1.Antimicrobial activity of metal nanoparticles
1.2.Leishmaniasis
1.2.1.Life cycle (Leishmania)
1.2.2.Available antileishmanial drugs
1.3.Green synthesis of metal nanopartieles
1.4.Silver (Ag) and gold (Au) nanoparticles
1.5.Copper and zinc oxide nanoparticles
1.6.Antileishmaniai activity of metal nanoparticles
1.7.Antileishmanial activity of biogenie selenium nanoparticles
1.8.Antileishmanial action of biogenic Ag and Au nanoparticles
1.9.Mechanisms and molecular targets in leishmania
1.10.Cytotoxicity of biogenic metal nanoparticles
Chapter 2
2.Materials and methods
2.1.Materials and chemicals
2.2.Preparation of plant extracts
2.3.Phytosynthesis of Ag nanoparticles
2.4.Phytosynthesis of gold nanoparticles
2.5.Amphotericin B conjugated AgNPs
2.6.Preparation of ehitosan funetionalized nanoparticles
2.7.Characterization
2.8.Biological applications
2.8.1.Antibacterial efficacy of Ag and AuNPs
2.8.2.Antifungal activity of Ag and AuNPs
2.8.3.Antileishmanial activity
2.8.4.Investigation of reactive oxygen species(ROS)
2.8.5.Bacterial ultra-structure
2.8.6.Membrane damage
2.8.7.Propidium iodide assay
2.9.Catalytic applications
2.9.1.Photocatalytic reduction of methylene blue
2.9.2.4-nitrophenol reduction
Chapter 3
3.1.UV-Vis spectroscopy
3.2.XRD
3.3.EDX spectral analysis
3.4.High-resolution TEM (HRTEM) study
3.5.FTIR analysis
3.6.Antibacterial activity
3.7.Antileishmanial activity
3.8.Summary
Chapter 4
4.1.Synthesis of AgNPs
4.2.Particles size and morphology
4.3.Zeta potential
4.4.XRD and Energy dispersive X-ray (EDX)
4.5.FTIR
4.6.Antileishmanial efficacy
4.7.Summary
Chapter 5
5.1.UV-Vis spectroscopy
5.2.X-Ray Diffraction and EDX profiling
5.3.Particles size and shapes
5.4.Zeta value of the prepared nanoparticles
5.6.FTIR
5.7.Antibacterial activity
5.8.Measurment of cell constituents release
5.9.Propidium iodide assay
5.10.Determination intracellular of reactive oxygen species
5.11.Summary
Chapter 6
6.1.AuNPs synthesis
6.2.XRD of AuNPs
6.3.TEM study of AuNPs
6.4.FTIR
6.5.Photocatalytic activity
6.6.Reduction of nitrophenol
6.7.Electroehemical behavior of AuNPs modified GC electrode
6.8.Summary
Chapter 7
Conclusion
Acknowledgments
Future plan
List of publications
Aftab Ahmad (Author)
PROF.QIPENG YUAN
Professor Dr.Yun Wei (Research Supervisor)
References