Responsive Multilayer and Hydrogel Based Drug for Resisting Bacterial Infection

目录

声明

Abstract

Table of Content

Chapter 1 Introduction

1．1Background of Antibacterial Biomaterials

1．2 Controlled Drug Delivery System

1．3 Antimicrobials for Antibacterial Biomaterials

1．4 Classification of Antibacterial Biomaterial

1．4．1 Inorganic Antibacterial Malerials

1．4．2 Synthesized organic Antibacterial Materials

1．4．3 Natural antibacterial Materials

1．5．1 Drugs Delivery Systems (DDS)

1．5．2 Redox responsive

1．5．3 Thermal Responsive

1．5．4 Enzyme Responsive

1．5．5 pH Responsive

1．6 Multilayer System for Drug Delivery

1．6．2 Natural Polymer based Multilayer System

1．6．3 Heavy Metal-Based Multilayer System

1．7 Other Advanced Methodologies for Responsive Drug Delivery System

1．8 Purpose and Innovativeness

Chapter 2 Fabrication of A pH and hyaluronidase dual-responsive multilayer-based drug delivery system

2．1 Preface

2．2．1 Materials

2．2．3 Adsorption and cross-linking of HA onto the multilayer surface

2．2．6Antibacterial test

2．3．1 Construction and characterization of multilayers surface

2．3．2 Loading and Release kinetics of GS into and from multilayer

2．3．3 Drug release kinetics of multilayers

2．3．4 Antibacterial behavior of multilayers

2．4 Conclusion

Chapter3 Fabrication of ahydrogel-based drug delively system with photothermal effect

3．2 Experimental

3．2．3 Polymer synthesizes

3．2．6 Determination of gelation efficiency

3．2．10 Statistical analysis

3．3．1 Analysis of the Chemical Structure

3．3．2 Gelation efficiency

3．3．3Swelling behavior

3．3．4 Assessment of GS Drug release from hydrogel

3．3．4 Assessment of photothermal effect

3．3．5 Antibacterial Activity

Chapter 4 Conclusion

Chapter 5 Deficiency and Prospect

References

PUBLICATIONS

Acknowledgments