The efficacy and safety of cryobiopsy versus forceps biopsy for interstitial lung diseases and lung tumours:a meta-analysis

摘要

Background:
　　Forceps biopsy (FB) is the most commonly used diagnostic tool for lung pathologies. FB is associated with a high diagnostic failure rate. Cryobiopsy (CB) is a novel technique providing a larger specimen size, few artifacts, more alveolar parts and superior diagnostic yield. CB, however, has drawbacks such as higher bleeding and pneumothorax rate.
　　Objective:
　　We conducted a meta-analysis to investigate the specimen area, diagnostic rate and bleeding severity in CB versus FB in interstitial lung diseases (ILDs) and lung tumours.
　　Methods:
　　A systematic literature search of PUBMED, BIOSIS PREVIEW and OVID databases was conducted using specific search terms. Eligible studies including RCTs and non-RCTs comparing cryobiopsy/cryotransbronchial biopsy (CB/CTBB) and forceps biopsy/forceps transbronchial biopsy(FB/FTBB) for specimen area, diagnostic rate and bleeding rate in ILDs and lung tumours were analyzed. Two reviewers independently extracted data and evaluated the quality of the studies.
　　Results
　　Eight studies involving 916 patients were analyzed. Specimen area (mm2) was significantly larger in CB/CTBB than FB/FTBB [Std Mean Difference=1.21, 95％ CI (0.94, 1.48), p＜0.00001].The diagnostic rate was significantly higher in CB/CTBB than FB/FTBB [RR 1.36, 95% CI (1.16, 1.59), p=0.0002] .There was no significant difference in bleeding severity [RR1.14, 95%CI (0.87, 1.49), p=0.35].
　　Conclusions
　　CB/CTBB shows superiority to FB/FTBB for specimen area and diagnostic rate. There is no significant difference in bleeding severity. CB/CTBB has better efficacy over FB/FTBB.

目录

封面

声明

目录

ABBREVIATIONS

英文摘要

Introduction

Objectives

Methods

Eligibility criteria

Search and selection of the studies

Data extraction

Quality assessment

Outcome evaluated

Data synthesis

Table 1:

Table2:

RESULTS

Search results

Characteristics of included studies

Quality assessment of trials

Specimen area

Diagnostic rate

Bleeding severity

Reporting bias

Discussion

Conclusion

参考文献

Publications

致谢