Subdural and Depth Electrode Placement in the Brain for Validation of MEG in Partial Epilepsy

摘要

Localization of epileptogenic zones in extratemporal epilepsy is a challenging problem. We speculate that using all modalities of data in an optimal way can facilitate the localization of these zones. In this paper, we propose the following steps to transfer all modalities of data in a single reference coordinate system: 1) Segmentation of subdural and depth electrodes, and cortical surface. 2) Building 3D models of the segmented objects. 3) Registration of preoperative MRI and postoperative CT, and magnetoencephalography (MEG). The above steps result in fusion of all modalities of data, objects of interests (electrodes and cortical surface), MEG analysis results and brain mapping findings. This approach offers a means by which an accurate appreciation of the zone of epileptogenicity may be established through optimal visualization and further quantitative analyses of the fused data. It also provides a ground for validation of less expensive and noninvasive procedures, e.g., scalp EEG, MEG.