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Risk factors and overlap between asthma and chronic obstructive pulmonary disease.

机译:哮喘和慢性阻塞性肺疾病的危险因素和重叠。

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摘要

Asthma and chronic obstructive pulmonary disease (COPD) are both defined by the presence of airflow obstruction, but they present distinguishing differences in terms of both risk factors and clinical phenotypes. The present study analyzes the risk factor for chronic obstructive diseases and asthma and it also made the discriminative analysis of clinic and functional factors which are significant for diagnosis. 278 patients aged over 18 presenting chronic respiratory symptoms were used. The average age of asthmatic patients was smaller compared to that of patients with COPD (46.23 vs. 55.10 vs. 63.59 (p<0.000l), the smoking habit presented a raised frequency in COPD patients compared to asthmatics (71% vs. 20%). The professional risk did not influence the diagnosis, even if it was present in 25% of the patients (p=0.217 NS). Analyzing, within the group, the criteria that influence the way a diagnosis is established, based on anamnesis data, previous medical documents, clinical examination and functional respiratory tests, the factors that proved being statistically significant were: age, smoker status (p=0.000), atopy (p=0.001) and the presence of the obstruction reversibility (p=0.016). COPD and asthma share common features that sometimes, in clinical practice, make it very difficult to differentiate them.
机译:哮喘和慢性阻塞性肺疾病(COPD)均以气流阻塞的存在来定义,但在危险因素和临床表型方面却存在明显差异。本研究分析了慢性阻塞性疾病和哮喘的危险因素,并对临床和功能性因素进行了判别分析,这些因素对诊断具有重要意义。使用了278名18岁以上,出现慢性呼吸道症状的患者。哮喘患者的平均年龄比COPD患者的平均年龄小(46.23 vs. 55.10 vs. 63.59(p <0.000l),与哮喘患者相比,COPD患者的吸烟习惯频率升高(71%vs. 20% )。即使在25%的患者中存在职业风险,职业风险也不会影响诊断(p = 0.217 NS)。根据回忆数据,在组内分析影响诊断方式的标准,先前的医学文献,临床检查和功能性呼吸检查,证明具有统计学意义的因素包括:年龄,吸烟者状态(p = 0.000),特应性疾病(p = 0.001)和阻塞性可逆性的存在(p = 0.016)。 COPD和哮喘具有共同的特征,在临床实践中,有时很难区分它们。

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