Nanoporous thin film platform for biophotonic sensors

摘要

A Nanoporous glass matrix is developed to encapsulate molecular probes for monitoring important biological parameters such as DO. The hydrophobic nanoporous host matrix is designed and fabricated using room temperature sol gel technique. The doped sol gel is then coated on biocompatible self adhesive patches or directly coated on the biocontainers. We demonstrate the application of this technique in non-invasive monitoring DO as well as oxygen partial pressure in a closed fermentation process as well as in a cell culture plate during bacterial growth. Dynamic response of sensor, sensitivity and accuracy is also demonstrated in this paper.