In-vivo Human retina imaging with 5um axial resolution, at 92000 A-scans/s with liim Spectral Domain OCT system

摘要

We have outfitted a 1060nm Spectral Domain Optical Coherence Tomography system with a prototype, high speed infrared linear array camera and a custom spectrally reshaped superluminescent diode to achieve 5 μm axial resolution at 91,911 A-scans/s image acquisition rate in-vivo in the human retina. 4dB loss of sensitivity was observed as a result of the reduced integration time (7μs) of the fast camera as compared to similar commercially available cameras with 14μs integration time and 47kHz readout rate. Fewer motion artefacts were observed in the retinal images acquired with the fast camera, while the higher axial resolution along with deeper penetration allowed for improved visualization of fine morphological details such as retinal and choroidal capillaries and the deep choroidal structure.