CRANIOFACIAL BONE TISSUE ENGINEERING USING MEDICAL IMAGING, COMPUTATIONAL MODELING, RAPID PROTOTYPING, BIORESORBABLE SCAFFOLDS AND BONE MARROW ASPIRATES

摘要

The clinical goals for craniofacial skeletal reconstruction are multifaceted. Aesthetic and functional considerations often dictate the use of mo dable implant materials. However, in most cases these three-dimensional shaped transplants must also provide immediate structural integrity. In addition, to minimize periimplant morbidity, the host-graft interface should not produce an immunological or inflammatory response. Bone tissue engineering has emerged as a potential method to address the problems of autogenic bone grafting as well as allo- and xenoplastic materials. We report the three month results of a study in an immuno-competent model, the aim of which was to treat complex craniofacial defects.