Intraoperative optical coherence tomography using an optimized reflective optical relay, real-time heads-up display, and semitransparent surgical instrumentation

摘要

Ophthalmic surgical maneuvers are currently limited by the ability of surgeons to visualize and manipulate semitransparent tissue layers as thin as tens of microns. We describe several iterative advances in iOCT technology, including a novel iOCT system, real-time heads-up display (HUD) feedback, visualization of intraoperative maneuvers, and OCT-compatible surgical instrumentation. Simulated surgical maneuvers were performed on freshly enucleated porcine eyes. Subretinal space cannulation with injection was performed and imaged using spatial compounding. The optical properties of semitransparent materials were quantified to identify OCT-compatible substrates, and surgical instrument prototypes were machined, including corneal, surgical picks, and retinal forceps.