THERAPEUTIC MISADVENTURES: CASES OF DRUG INTERACTIONS, DRUG TOXICITY, OTHER DISASTERS: PART I

摘要

Most of the adverse drug reactions encountered in the clinic are dose-dependent. They may be an extension of the drug's intended pharmacologic effect (for example, hypotension from amlodipine), or unrelated to the drug's intended effect (e.g. retinotoxicity from fluoroquinolones). Dose dependent reactions are relatively predictable, and can often be prevented through therapeutic drag monitoring, if available. Dose dependent toxicity can also result from unanticipated adverse drug interactions.