首页> 外文会议>ASME summer bioengineering conference;SBC2012 >CAPTURE OF MAGNETIC MICROSPHERES IN ELECTROKINETIC FLOW FOR APPLICATION IN LAB-ON-CHIP DEVICES
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CAPTURE OF MAGNETIC MICROSPHERES IN ELECTROKINETIC FLOW FOR APPLICATION IN LAB-ON-CHIP DEVICES

机译:电动微流中的磁性微球捕获,用于芯片实验室设备

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摘要

Isolation of bio-molecules, cells and pathogens for immunoassays is a critical component in micro total analysis systems (uTAS). Magnetophoretic technique is often used for separation of such target species, where magnetic beads tagged with specific antibodies against cell surface epitopes, are captured in the microfluidic device. In this study, a numerical model is developed for capture of beads under an external magnetic field in electrokinetically driven flow. The results indicate an increase in the number of beads captured when the magnetic field is higher and the flow is driven by lower electric fields.
机译:分离生物分子,细胞和病原体以进行免疫测定是微型整体分析系统(uTAS)的关键组成部分。磁泳技术通常用于分离此类目标物种,其中在微流体设备中捕获了带有针对细胞表面表位的特异性抗体标记的磁珠。在这项研究中,建立了一个数值模型,用于在电动驱动流中的外部磁场下捕获磁珠。结果表明,当磁场较高且流动由较低电场驱动时,捕获的磁珠数量增加。

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