首页> 外文会议>ASME summer bioengineering conference;SBC2012 >MULTI-SCALE STRUCTURAL AND TENSILE MECHANICAL RESPONSE OF ANNULUS FIBROSUS TO OSMOTIC LOADING
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MULTI-SCALE STRUCTURAL AND TENSILE MECHANICAL RESPONSE OF ANNULUS FIBROSUS TO OSMOTIC LOADING

机译:纤维纤维对渗透负荷的多尺度结构和拉伸力学响应

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The annulus fibrosus (AF) is a multi-lamellar fibrocartilagenous ring in the intervertebral disc. The variation of biochemical composition from the outer to the inner AF is largely responsible for the heterogeneous mechanical properties. In vitro tissue-level studies require mechanical testing in aqueous buffers to avoid tissue dehydration. The varying glycosaminoglycan (GAG) contents from outer to inner AF suggest that the response to high and low PBS osmolarity may also be different with radial position. Previous studies in tendon and ligament have been conflicting: soaking tendon fascicles in PBS decreased tensile modulus and treating ligament in buffer had no effect on modulus.
机译:纤维环(AF)是椎间盘中的多层纤维化软骨环。从外部AF到内部AF的生化组成变化主要是造成异质机械性能的原因。体外组织水平研究需要在水性缓冲液中进行机械测试,以避免组织脱水。从外部到内部AF的糖胺聚糖(GAG)含量变化表明,对高和低PBS渗透压的响应随径向位置也可能不同。先前在肌腱和韧带中的研究一直存在矛盾:将肌腱束浸泡在PBS中会降低拉伸模量,而在缓冲液中处理韧带对模量没有影响。

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