A FEATURE-BASED MECHANO-ELECTRIC FINITE ELEMENT MODEL OF THE LEFT ATRIUM WITH PRESSURE-TO-MITRAL-FLOW COUPLING

摘要

The modeling of complex biological systems requires many degrees of sophistication. Among them, we can enumerate heterogeneous tissue properties, a complex geometry that can be obtained only through proper imaging techniques and the interaction of the organ of interest with the surrounding structures. In the case of the left atrium, three physical domains govern its behavior: mechanical, electrical and fluidic. Different mechanical conditions, in terms of stresses and consequent strains, affect the electrical activity occurring across the tissue, and jointly, the mechanical and electrical activities regulate the correct and timely contraction of the chamber.