Enhancing the Throughput of Catalyst Screening Labs by Integration of a High Pressure Microplate Reactor

摘要

In the future laboratories require particularly multivariate laboratory systems. The devices used in these systems are characterized by an increase of the reactions per time unit and the reduction of the reaction volumes with consideration of compact dimensions. They have to be variable integrable into laboratory robot systems in hard- and software. The multi-parallel high pressure reactor HPMR 50-384 enables the simultaneous execution of 384 reactions in a reaction module under reaction pressures up to 50 bar and temperatures in the range from 0 to 100掳C. The mixing of the reagents is realized with magnetically propelled stir discs with a velocity up to 500 rpm. The reaction module is based on a commercial microplate made of polypropylene, MultiChem驴 or glass. With a sealing mat, a support frame and a perforated plate such a microplate will be completed to a reaction module. By an injection system in the lid of the pressure tank the gas exchange in the reaction vessels can be ensured. The HPMR 50-384 enables an excellent gas exchange in the pressure tank and thus the handling of air sensitive compounds. The possibility of integration into a laboratory robot system or the connection to a LIMS makes the HPMR 50-384 an all-purpose reaction system.