Laser based manufacturing of channels and improvement of their lifetime with sol-gel coatings

摘要

A preclinical device that mimics half blood vessel by using laser technologies has been developed. By employing a Nd:YVO_4 laser a channel has been manufactured over soda-lime glass. Using a CO_2 laser combined with a roller furnace, a thermal treatment has been applied to the channel to enhance its quality. The glass structure was employed as master to replicate the channel m PDMS by soft-lithography. To avoid the deterioration of the PDMS, channels were coated with three different sol-gel coatings compositions. Endothelial cells were cultured over the channels to determine the most suitable surface for cell growing.