Preparation and In-Vitro Dissolution of Ibuprofen: Soluplus Solid Dispersion

摘要

Introduction: Ibuprofen is widely used in treatment of mild to moderated pain and fever. However, according to Biopharmaceutical Classification System (BCS) it is classified as Class II compound having high permeability and low solubility, thus the rate limiting step to avoid delaying in analgesic effect is to be available in soluble state. Objective: To prepares and characterize Ibuprofen:Souplus solid dispersion using co-evaporation technique. Methods: Various ration of Soluplus (0, 10, 30, 50, 70, 80, 90, and 100 %) was first dissolved in a common solvent followed by adding the complementing ratio of Ibuprofen. The solvent was removed under fume hood overnight. The thin film formed after evaporation was collected, compressed and tested for in-vitro dissolution at phosphate buffer pH 7.2. The physical appearance of the film also was tested. Results:At 40% Soluplus the dissolution of Ibuprofen was around 25 % at 30 min compared with 15% Soluplus showed around 80% resales at the same time interval. 10% soluplus released 100% at 30 min. Interestingly, after 8-10 hr. The release profile was more sustained until 24 hr. Regardless the % of Soluplus. Conclusion: Sustained release profile of Ibuprofen:Soluplus solid dispersion can be achieved at lower % of Soluplus.