Research on abnormal data processing and constructing network based on network pharmacology

摘要

Complex networks exist widely in nature and human society, from the Internet to chemical reactions, biological food chain, and then to human society, interpersonal relationships, cooperation between people, science and technology citation and so show a complex network topology characteristics. Network pharmacology is based on the theory of system biology, network analysis of biological systems, select the characteristics of signal nodes for multi-target drug molecular design of new disciplines. Network pharmacology and traditional pharmacology of the biggest difference is that it is from the perspective of systems biology and biological network to explain the occurrence and development of the disease process, from the perspective of improving or restoring the balance of biological networks to understand drug interactions with the body and to guide new drugs. In this paper, we first obtain the target protein and small molecule compounds from the public database, semi-flexible docking calculation of the pre-treated target protein and small molecule, and extract the molecule-target interaction network map with better docking results. Several problems and possible application directions in the field are proposed.