Bioactive coatings for vascular implants: a promising strategy using oriented tethering of EGF on chondroitin sulfate

摘要

This work demonstrates the advantages of CS as a sublayer for oriented immobilization of growth factors, and the improvement of grafting efficiency and bioactivity brought by oriented tethering compared to random grafting. Thanks to the versatility of coiled/coil tethering, CS may be used as a sublayer co-capture of several Ecoil-tagged growth factors. The benefit of such a system would be tremendous since it would allow to fine-tune implant bioactivity for specific applications by changing the ratio of growth factors on the surface.