In vitro anti-Influenza a virus activity of konjac oligo-glucomannan sulfate

摘要

Glucomannan extracted from konjac was sulfated (konjac oligo-glucomannan sulfate, OGMS) to show selective anti-Influenza A virus activity in vitro using MDCK cell line as the host cell of Influenza A virus. OGMS straight inhibited the virus according to different groups and IAV-RNA Replication in MDCK cell by RT-PCR. The studies indicated that OGMS mainly acted as virus protein inhibitor and its IC50 was 0.03125 mg/mL by Reed-Muench method; IAV-RNA Replication was inhibited as well. All these indicated that OGMS had evident in vitro anti-Influenza A virus activity.