Formulation And Evaluation Of Sustained Release Orally Disintegrating Tablets OfMetoclopramide Hydrochloride Intended For Gastro retention

摘要

Metoclopramide Hydrochloride is used for themanagement of nausea and vomiting due to migraine,cancer chemotherapy, tardive dyskinesia and gastroesophageal reflux disorders. The drug has a shortbiological half-life and is administered in a dose of 10–15mg q.I.dd1. Also the drug finds applicability in pediatricand geriatric patients who prefer patient compliantproducts. Patients who have difficulty in swallowingcannot swallow a sustained release tablet or capsule as theformulation is required to be taken intact. Also thepatients who are suffering from emesis would prefer aformulation to be consumed without water. Hence anorally disintegrating sustained release gastro retentivetype of dosage form was formulated so as to get asustained effect by means of gastro retention as well asprovide the ease of administration.. 2-4 Taste masking of thedrug was carried out to mask the bitter taste. Sustainedrelease floating pellets were formulated and compressedto form orally disintegrating tablets. In vitro evaluationwas carried out to assess disintegration, wetting, drugrelease, buoyancy and assay. In vivo evaluation wascarried out to confirm the taste masking, oraldispersibility, buoyancy and gastro retention. Theformulated tablet produced a very short disintegrationtime in oral cavity and showed buoyancy and drug releasefor period of 12 hrs. Also the gamma scintigraphy studiesconfirmed the gastro retention.