Chemosensitization of Multi-Drug Resistant Human Small Cell Lung Cancer Cells to Doxorubicin

摘要

Pluronic copolymers have the potential to sensitize multi-drug resistant cancer cells. In this study we investigate the chemosensitizing effects of two Pluronic copolymers (F127, P103) to Doxorubicin in human small-cell lung carcinoma cells. Results indicate that P103 below its critical micelle concentration increase the cytotoxicity of Doxorubicin in resistant cells.