Abstract: The broad, long term objective of this work is the development of Photodynamic Therapy (PDT) for application in the clinical management of patients with port wine stain (PWS). PDT involves the use of an exogenous drug which is concentrated in a targeted tissue. When irradiated at wavelengths specifically absorbed by the drug, selective destruction of the targeted tissue, without the production of heat, occurs. The results of this preliminary study demonstrate in human PWS patients that a photosensitizer, such as PHOTOFRIN$+R$/, activated by red light at the appropriate therapeutic wavelength, can cause destruction of subsurface blood vessels in the skin with a high degree of specificity, and further study appears warranted. !13
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机译：摘要：这项工作的广泛而长期的目标是开发光动力疗法（PDT），将其用于鲜红斑痣（PWS）患者的临床管理中。 PDT涉及使用集中在目标组织中的外源性药物。当以药物特异性吸收的波长进行照射时，会选择性破坏目标组织，而不会产生热量。这项初步研究的结果表明，在人类PWS患者中，以适当的治疗波长被红光激活的光敏剂（例如PHOTOFRIN $ + R $ /）可以高度破坏皮肤中的地下血管。 ，并且有必要进一步研究。 ！13
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