Comparison of Ho:YAG Tm:YAG and argon lasers for fusion of intestinal tissues

摘要

Abstract: Numerical modeling and experimental verification studies were conducted to compare continuous wave Ar, Tm:YAG, and Ho:YAG fusion characteristics in rat intestinal tissues. Spot sizes, powers, and activation times were varied according to laser characteristics. Exposed transected bowel wall was apposed and irradiated to obtain fusion in vivo. Tissue surface temperature distributions were measured with a thermal camera in the 8 to 12 $mu@m band for calibration of the numerical models. The lasers were operated at fixed power, duration, and spot size. Experimental results were analyzed histologically to determine the extent of changes in submucosal collagen as indicated by birefringence loss. Modeling studies based on damage kinetics were conducted for the Tm:YAG and Ho:YAG experiments to study the microscale thermal and damage accumulation phenomena. Comparisons between predicted and measured damage boundaries showed favorable agreement. !9