Association rule derivation for side effects of medical supplies and its application

摘要

In drug discovery, it is very important to predict the side effect of the drug accurately. The prediction algorithm of the drug side effect is presented in this study. This algorithm is based on the concept of the structure-activity relationship. Firstly, the drug side effects are gathered from the registration of medical products by using text mining. Next, the chemical structure information of the drug is obtained from the PubChem data base. Then, the association rules between the chemical structure and the side effects are defined. The associate rules are applied to the prediction of the side effect of 10 chemical products.