Synthesis and Characterization of Fluorescent Dyes-Magnetic Nanoparticles for Bioimaging Applications

摘要

Magnetic-fluorescent nanoparticles have been emerging as potential bimodal probes in the area of bioimaging. However, near-infrared (NIR) fluorescent dye as a fluorescent material for bimodal probe remains unexplored. The tailor-design of NIR cyanine dye is challenging. Herein, we report the synthesis and characterization of novel functional IR 820 dye. This modified IR 820 has been successfully conjugated with long and short back-bone chain polymers. All these compounds preserve good water solubility and photochemical properties. The magnetic-fluorescent bimodal probe has been demonstrated, wherein the magnetic nanoparticles have been coated with dye-polymer. The cytotoxicity studies on HeLa cells show that MNP@dye-polymer with short back-bone chain has better cell viability.